Novel drug mimics feeling of 'fullness'

 

Hebrew University researchers have discovered how to lose weight and not go hungry with the development of a new drug that imitates the sensation of 'fullness'.

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While millions of people in the world suffer from obesity and there is no 'magic bullet' that has yet provided a universally accepted solution, a researcher at the Hebrew University of Jerusalem feels he has come up with a practical weight loss solution for the obese person without his having to feel hungry.

For this development, Yaniv Linde, a 32-year-old PhD student of Professor Chaim Gilon in the Department of Organic Chemistry at the Hebrew University, has been named a first place winner of a Kaye Innovation Award, which was presented today during the 70th meeting of the Hebrew University Board of Governors.

Linde and team have developed a compound that mimics the activity of the naturally occurring hormone called aMSH.

This hormone is excreted during eating and binds to a receptor in the brain called MC4R, and when this communication occurs on a substantial level, the brain sends out a signal to the taker that they feel full.

Overcoming obesity by curbing the appetite

The Hebrew university researchers developed a novel method for synthesising a peptide (a compound linking two or more amino acids) which can serve as an analogue to the naturally occurring aMSH hormone.

They were able to demonstrate that their peptide, which they call BL-3020, displayed good metabolic stability to intestinal enzymes when swallowed, and that it was able to cross the intestinal wall and gain access into the blood stream.

Once in the blood, it could make its way to the MC4R receptor and close the circuit to send out the 'full' signal.

The result is that a person seriously wishing to overcome obesity could take this compound orally in order to curb his appetite, thus leading to natural weight loss.

In experiments with mice, it was shown that a single oral administration of BL-3020 led to reduced consumption over a period of 24 hours.

Over a 12-day period of daily dosages, the mice weighed 40 per cent less than the average for mice of their size and age that were not being given the compound.

The peptide has been patented in Europe and the US; commercial firm Bioline RX Ltd of Jerusalem has purchased development rights from Yissum, the Hebrew University’s technology transfer company, and is currently working towards creating a commercial anti-obesity drug.

The Kaye Innovation Awards at the Hebrew University have been awarded annually since 1994.

Isaac Kaye of England, a prominent industrialist in the pharmaceutical industry, established the awards to encourage faculty, staff, and students of the Hebrew University to develop innovative methods and inventions with good commercial potential which will benefit the university and society.

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